Renal tubular acidosis inducede ffects in the process of renal interstitialfibrosis / 中国医师杂志

ABSTRACT

Objective Study of renal tubular acidosis induced effects in the process of renal interstitial fibrosis .Methods Twenty rats in the sham operation group , the experimental group UUO40 only, Screening of renal tubular acidosis group , After opera-tion 7, 14, 21, 28 days, the rats were killed in batches, kidney function , organization and determination of integrin linked kinase in renal tissue immunohistochemistry and Western blot ( ILK ) expression were detected .Results UUO +RTA group than in UUO group, under the light microscope , inflammatory cell infiltration and interstitial fibrosis were more serious; Protein expression in control group only a small amount of ILK protein ,Almost no FN protein deposition ,Deposition of UUO expression of group ILK and FN proteins increased,and UUO+RTA group was more than UUO group .Conclusions In obstructive nephropathy , renal tubular acidosis can be deposited and expression of FN and up -regulation of ILK protein .