MiRNA-101 suppresses growth and invasion of human brain glioma U251 cells / 中国医师杂志

ABSTRACT

Objective To observe effects of forced expression of miRNA -101 on glioma U251 cells proliferation and invasion. Meth ods MiRNA-101 oligoneucleotide was transfected into U 251 cells with liposome .MTT assay measured cell proliferation and Tr-answell assay detected cell invasion .Results Compared with control groups ,the growth and invasion of U251 cells transfected with miRNA-101 were decreased markably .Conclusions MiRNA-101 may play important role in inhibiting glioma cell growth and inva-sion.