The expression of BCORL1 and E-cadherin in gastric carcinoma and their correlation analysis / 重庆医学

ABSTRACT

Objective To investigate the expression of BCORL1 and E-cadherin and their correlation analysis in gastric carcino-ma .Methods We freshly collected 58 samples of surgically resected paired gastric carcinoma and normal tumor-adjacent tissues and detected BCORL1 and E-cadherin expression in the samples using immunohistochemical staining .The correlation between BCORL1 and E-cadherin protein expression was analysed .Results The protein expression of BCORL1 in gastric carcinoma tissues was sig-nificantly upregulated compared to those of the normal tumor-adjacent tissues(60 .3% vs .17 .2% ,P=0 .000) ,but expression of E-cadherin in gastric carcinoma tissues was significantly lower than those in the normal tumor-adjacent tissues (27 .6% vs .63 .8% , P=0 .000) .Clinicopathological analysis suggested that EphA2 and E-cadherin protein expression were associated with histopatho-logical differentiation ,depth of invasion ,lymph node metastasis and TNM stage(P<0 .05) .BCORL1 was significantly negative cor-related with E-cadherin protein in gastric carcinoma(r= -0 .571 ,P=0 .002) .Conclusion The high-expression of BCORL1 is cor-related with malignant clinicopathological characteristics ,and BCORL1 is negative associated with E-cadherin ,suggesting that BCORL1 promotes tumor progression and metastasis through transcriptional regulating E-cadherin in gastric carcinoma .