Pathological research about taking Actovegin orally to cure acute radiation esophagitis / 重庆医学

ABSTRACT

Objective To evaluate the feasibility and effect of taking Actovegin orally in cureing acute radiation esophagitis ,and to compare the curative effect of oral drugs and abdominal cavity medicine .Methods Thirty male mouses were randomly divided in-to three groups after upper moiety esophageal radiationthe control group(irradiation only) ,the oral group(take Actovegin orally) , and the celiac injection group .The weight chang was tracked record weekly ,and the mouses were killed in batches at the seventh day ,the fourteenth day ,and the twenty eighth day .The grade about esophageal breakage ,inflammation and immunochemical colour-ation by TGF-βwere analysed .Results Esophageal breakage in the oral group and the celiac injection group had not significantly deffrence (P=0 .318) ,but they had better than the control group(P<0 .05);The celiac injection group had less weight decrease than the control group(P=0 .030) .Conclusion The mouses′cacotrophia with acute radiation esophagitis can be improved by Acto-vegin mainline .Taking Actovegin orally can reduce esophageal damnification .