Research Progress in the mechanism of histone deacetylase inhibitors as radiosensitizers / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 425-428, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-453380
ABSTRACT
One leading research target of modern tumor radiotherapy is to increase radiosensitization of tumor and improve curative effect of radiotherapy.Histone deacetylase inhibitors are epigenetic drugs that can play a part in radiosensitization through means of induction of apoptosis,inhibition of repair of DNA doublestrand breaks,cell cycle arrest,improvement of tumor cell hypoxia and increase of reactive oxygen species.There is an urgent need to develop biomarkers based on these pathways,which can promote clinically individualized treatment.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2014
Type:
Article
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