The clinical analysis of the efficacy of creatine phosphate sodium therapy in children with primary myocarditis / 中国医师进修杂志

ABSTRACT

Objective To analyze the characteristics of primary myocarditis,and investigate the clinical efficacy of creatine phosphate sodium therapy in children with primary myocarditis.Methods A retrospective analysis of 56 cases of primary myocarditis in children,divided into control group and treatment group by random digits table method,each group 28 cases.Two groups of patients received conventional treatment,the treatment group was added the use of creatine phosphate sodium,after 14 d of continuous treatment,the clinical efficacy,myocardial enzymes (creatine kinase,creatine kinase-MB,lactate dehydrogenase),troponin and ECG in both groups were observed.Results After treatment,the total effective rate in treatment group was significantly higher than that in control group [89.3％(25/28) vs.53.6％ (15/28)] (x2 =4.094,P ＜0.05).The myocardial enzymes after treatment in both groups significantly improved compared with before treatment (P ＜ 0.05),the improvement in treatment group was better than that in control group,the difference was statistically significant (P ＜ 0.05).The negative conversion ratio of troponin in treatment group was significantly higher than that in control group (16/18 vs.9/17)(x2 =6.052,P ＜ 0.05).The total effective rate of ECG in treatment group was significantly higher than that in control group (x2 =3.896,P ＜ 0.05).Conclusions Creatine phosphate sodium for the treatment of children with primary myocarditis has better clinical efficacy,physiological indicators of myocardial enzymes,such as troponin significantly improve,with some clinical significance.