Long-term effects of sertraline on clinical symptoms, executive and occupational functions of patients with obsessive-compulsive disorder / 中华行为医学与脑科学杂志

ABSTRACT

Objective To explore the long-term effects of sertraline on clinical symptoms,executive and occupational functions of patients with obsessive-compulsive disorder.Methods By randomly grouped,48 cases with obsessive-compulsive disorder were treated with sertraline as the study group and 44 cases treated with clomipramine as the control one.They were maintained with relative stable drug dosage after ill-condition improving,and all the subjects were also treated with psychological treatment and rehabilitation activities.The incidences of obsessive-compulsive symptoms before and after 2,4,6 and 8 weeks of treatment were investigated and compared.Yale-Brown obsessive-compulsive scale(Y-BOCS) were used to evaluate the efficacy according to the Y-BOCS reducing rate.The trail making test A and B (TMT-A and TMT-B),Stroop test and the Social Disability Screening Schedule (SDSS) were used at 8th weekend and 2 year's follow-up to evaluate and compare the two groups' executive and occupational functions.Results The incidences of 4 weeks' obsessive symptoms (62.5％)and 6 weeks' compulsive symptoms(18.8％) showed significantly lower in the study group than those in the control one (81.8％ and 38.6％,P＜0.05).But the obsessive-compulsive symptoms incidences at 8 weeks(8.3％-22.9％) and 2 years' treatment(6.3％-12.5％) in study group showed no statistical meaning differences from the control (20.5％-40.9％ and 15.9％-22.7％,P＞0.05).The clinical efficacy also showed no statistical difference between the two groups (P＞0.05).After two years' treatment,the times of TMT-B ((46.4±6.4) s) and Stroop-CW ((132.2± 14.9) s)of the study group showed significantly shorter than those of the control ((49.3±6.5) s,(138.8± 15.7)s,P＜0.05),and the total score and occupational function score of SDSS were significantly lower (P＜0.01) but the employment rates (72.9％)higher in the study group than those in the control (47.7％,P＜0.05).The total side-effect rate of the study group (12.5％) showed significantly lower than that of the control (43.2％,P＜0.05).Conclusion Sertraline is as effective as clomipramine for treatment clinical symptoms of obsessive-compulsive disorder.But it shows better long-term efficacy in improving executive and occupational social functions.