Effect observation of fexofenadine combined with tripterygium glycosides in treating chronic urticaria / 重庆医学

ABSTRACT

Objective To study the effect of tripterygium glycosides(TG)in treating urticaria chronica(UC).Methods 91 cases of UC in our hospital from February 2012 to March 2013 were randomly divided into the observation group(45 cases)and the con-trol group(46 cases)according to the digital method.The control group was treated with fexofenadine,while on this basis the obser-vation group was added with TG.The UAS,VAS and LFS scores before and after treatment,curative effects,serum IL-4,IFN-γand IgE levels change and adverse reactions were compared between the two groups.Results The VAS,LFS and UAS scores after treatment in the observation group were significantly lower than those before treatment and the control group after treatment;the curative effect after 4-week treatment in the observation group was significantly higher than that in the control group;the IL-4 and IgE levels after treatment in the observation group were significantly lower than those before treatment and the control group after treatment;the IFN-γlevel was significantly higher than that before treatment and the control group after treatment,all the differ-ences above were statistically significant(P0.05).Conclusion TG combined with fexofenadine in the treatment of UC has better effect.