Research progress of cell division cycle 25 homolog C and tumor radiosensitivity / 国际肿瘤学杂志
Journal of International Oncology
; (12): 511-514, 2014.
Article
in Zh
| WPRIM
| ID: wpr-454284
Responsible library:
WPRO
ABSTRACT
AsoneoftheCdc25phosphatasefamilymembers,Cdc25Cplaysanimportantroleinregu-lating mitosis of eukaryotic cells.In eukaryotic cells,CDK1-cell cycle protein B (CyclinB)compound mainly control the process of G2-M.The activity of Cdc25 C is the key in cell cycle into M phase.It activates CDK1-cyclinB complexes to promote cells from G2 to M phase .Improving Cdc25 C activity can promote the G2-M phase transition,and remove the G2-M phase retardation induced by ionizing radiation,preventing the damaged DNA from repaired into the phase of cell division,resulting in cell death caused by excessive cell proliferation, thus enhance radiosensitivity.
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WPRIM
Language:
Zh
Journal:
Journal of International Oncology
Year:
2014
Type:
Article