Relationship of HPV 16 and HPV 18 with esophageal squamous cell carcinoma in Minnan area / 中国肿瘤临床

ABSTRACT

To detect the expression of the human papilloma virus (HPV) 16 and HPV18 in esophageal squamous cell carcinoma in Minnan area. Methods: Real-time fluorescence quantitative polymerase chain reaction (FQ-PCR) was applied to detect HPV DNA in 100 esophageal carcinoma sample and 100 normal tissues beside the tumor. Results:The positive rates of high-risk HPV 16 and HPV 18 infection in Minnan esophageal carcinoma and in normal tissues beside the tumor were 14.00%, 15.00%and 7.00%, 8.00%, respectively. The positive rates of lymph node and non-lymph node metastases were 40.98%and 10.25%, respectively. These re-sults exhibited statistical significance (P0.05). Conclusion:HPV16 and HPV 18 infection was correlated to esophageal squamous cell carcinoma in Minnan ar-eas. Such infection may also contribute to the occurrence and development of esophageal squamous cell carcinoma.