Expression and prognostic significance of HLA-F in hepatocellular carcinoma / 中华普通外科杂志
Chinese Journal of General Surgery
; (12): 630-633, 2014.
Article
in Zh
| WPRIM
| ID: wpr-454340
Responsible library:
WPRO
ABSTRACT
Objective To investigate the expression of human leukocyte antigen F (HLA-F) in hepatocellular carcinoma (HCC) tissues and to evaluate its relation to clinicopathological features and prognosis of HCC.Methods HLA-F expression of tumor lesions and their adjacent normal liver tissues from 115 HCC patients were analyzed by immunohistochemistry,and its relationship between HLA-F expression and the clinicopathological features and prognosis of HCC patients was also analyzed.Results HLA-F expression was positive in 47.0% (54/115) of the HCC lesions and in 10.6% (7/66) of the normal liver tissues (x2 =24.799,P < 0.05).HLA-F expression in HCC lesions was significantly correlated with portal vein invasions (x2 =7.644,P =0.006),tumor number (x2 =4.210,P =0.040) and patient sex (x2 =6.759,P =0.009).The mean survival time of the HLA-F positive HCC patients was 34.0 months(95% CI:27.5-40.5 months),which was significantly shorter than that of HLA-F negative HCC patients(44.6 months,95% CI:38.3-50.9months) (x2 =5.148,P =0.023).HLA-F expression was an independent predictor of overall survival of HCC patients.Conclusions Positive HLA-F expression is negatively correlated with the prognosis of HCC patients.
Full text:
1
Index:
WPRIM
Type of study:
Prognostic_studies
Language:
Zh
Journal:
Chinese Journal of General Surgery
Year:
2014
Type:
Article