Analysis of ceftriaxone efficacy in children with bronchial pneumonia and inflammation factors / 中国基层医药

ABSTRACT

Objective To investigate the effects of the levels of inflammatory cytokines on children with bronchial pneumonia ceftriaxone.Methods 85 cases of children with bronchial pneumonia were randomly divided into observation group (n =43) and control group (n =42).Two groups were treated on the basis of penicillin (200 000U/kg,2 times/d),the observation group ceftriaxone (20mg/kg,1 times/d) treatment on the basis of the times,7d course of treatment.The clinical efficacy of two groups were compared.The levels of C-reactive protein (CRP),interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) before and after treatment,1d,3d,5d,7d were analyzed.Results The total effective rate of observation group was 96.97％,the control group was 75.00％,the total efficiency of the two groups had significant difference (x2 =5.236,P =0.000).After treatment,fever,cough,wheezing,rales symptom score decreased significantly compared with pre-treatment,post-treatment observation group political scores were significantly lower than those of the control group,the difference was statistically significant (t =3.425,3.622,3.712,3.812,P ＜ 0.05).The levels of C RP (4.28 ± 1.07) mmol/L,IL-6 (7.21 ± 2.07) mmol/L,TNF-α(15.36 ± 3.78) mmol/L of observation group after treatment were significantly lower than those of before treatment and control groups at the same time,while the control group after treatment 5d CRP,IL-6,TNF-α levels lower than before treatment,the difference was statistically significance (P ＜ 0.05).Conclusion Ceftriaxone can effectively relieve symptoms of pneumonia in children,quickly reduce the levels of inflammatory factors,improve clinical outcomes in children.