Risk Factors for Aseptic Meningitis in Herpes Zoster Patients
Annals of Dermatology
;
: 283-287, 2017.
Article
in English
| WPRIM
| ID: wpr-45442
ABSTRACT
BACKGROUND:
Herpes zoster (HZ) is caused by reactivation of latent varicella-zoster virus (VZV) infection. HZ-associated aseptic meningitis, a rare complication of HZ, can require hospitalization and a long treatment period.OBJECTIVE:
A retrospective study was performed to identify potential factors associated with HZ-associated aseptic meningitis development.METHODS:
We included all outpatients and patients admitted in the neurology and dermatology departments of a single tertiary center, who were diagnosed with HZ for two years. Among 818 patients, 578 patients were eligible for analysis.RESULTS:
The demographics and potential risk factors were compared between the uncomplicated HZ group (n=554) and aseptic meningitis group (n=24). Among the potential factors, the dermatological distribution of skin rash and gender showed statistically significantly different between the two groups. Patients with craniocervical distribution of HZ accounted for 87.5% (n=21) of the aseptic meningitis group and 54.3% (n=301) of the uncomplicated HZ group (p=0.043). The aseptic meningitis group had more men (66.7%, n=16) than the uncomplicated HZ group (42.8%, n=237, p=0.033). Patients with craniocervical distribution had an odds ratio (OR) of 5.884 (p=0.001) for developing aseptic meningitis when compared with the other dermatome involvements. Additional logistic regression analysis resulted in a fading between gender difference (p=0.050) and craniocervical involvement having an OR of 5.667 for aseptic meningitis (p=0.006).CONCLUSION:
In HZ patients, skin rash with craniocervical distribution and male gender were associated with a higher risk of aseptic meningitis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Outpatients
/
Logistic Models
/
Odds Ratio
/
Demography
/
Retrospective Studies
/
Risk Factors
/
Herpesvirus 3, Human
/
Dermatology
/
Exanthema
/
Herpes Zoster
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Humans
/
Male
Language:
English
Journal:
Annals of Dermatology
Year:
2017
Type:
Article
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