Your browser doesn't support javascript.
loading
Inhibitory Effect of Polypeptide P161 Combined with Cisplatin on Proliferation of Multiple Cancer Cells / 医药导报
Herald of Medicine ; (12): 1288-1290, 2014.
Article in Zh | WPRIM | ID: wpr-454592
Responsible library: WPRO
ABSTRACT
Objective In vitro detection of anti-proliferative effects of P161 combined with cisplatin ( DDP) on multiple cancer cells. Methods Growth inhibition rates of HepG2, HT29, IE8, Panc-1 and MA-782 treated by different concentrations of DDP,P161 and P161 combined with DDP were determined by MTT assay. Results DDP and P161 dose-dependently inhibited proliferation of multiple tumor cells. A synergistic effect was found in DDP combined with P161 and there was a significant difference in the effect between DDP combined with P161 and DDP alone (P<0. 05). DDP dose could be decreased to reach the same inhibitory effect. In the same concentration gradient of DDP combined with P161,the inhibition rate of Panc-1 was low and that of MA-782 was high. Conclusion P161 can increase the sensitivity of tumor cells to DDP. The combination of P161 and DDP can reduce the effective therapeutic concentration of DDP.
Key words
Full text: 1 Index: WPRIM Language: Zh Journal: Herald of Medicine Year: 2014 Type: Article
Full text: 1 Index: WPRIM Language: Zh Journal: Herald of Medicine Year: 2014 Type: Article