Comparative ERP and behavior study of ADHD and normal children in mental arithmetic practice / 中华行为医学与脑科学杂志

ABSTRACT

Objective To compare the differences of event-related potentials (ERP) of left and right cerebral hemispheres and behavioral characteristics in the mental arithmetic practice between ADHD and normal children,and to explore the neural mechanisms of mental arithmetic by ADHD children.Methods ERP and behavioral data of 32 ADHD and 32 normal children in mental arithmetic,to illustrate,simple addition,subtraction and multiplication within 20 were recorded.Results ERP① The differences of N2 amplitudes in ADHD children 's left and right cerebral hemispheres while doing mental arithmetic,such as,addition,subtraction and multiplication were not statistically significant (addition(-6.2±7.3) μV,(-6.6± 8.1) pV ; subtraction(-5.5±6.4) μV,(-5.8± 6.5) μV ; multiplication(-5.9± 8.2) μV,(-6.0± 8.6) μV ; all P＞0.05).However,normal group's N2 amplitude of left hemisphere(F3) were obviously higher than those of the right hemisphere (F4),considered to be statistically significant difference (addition(-6.8±4.0) μV,(-5.9±4.3) μV ; subtraction(-7.5±4.8) μV,(-6.3±4.4) μV ;multiplication(-6.9±3.7)μV,(-5.7±4.4)pV ; all P＜0.05).② ADHD group's N2 amplitude of subtraction practice was significantly lower than that of addition and multiplication,while normal control group was the opposite.③There were not statistically difference between N2 incubation of left and right hemisphere while addition,subtraction,and multiplication were done (P＞0.05).Behaviorism① ADHD group's reaction time towards answer making were much longer than those of the normal control group (addition(983± 183) ms,(833± 164) ms ; subtraction(1005±160)ms,(859±170)ms;multiphcation(975±180)ms,(836±175)ms; P＜0.05).② Accurate rateADHD group were all lower than those of normal group.Conclusion There were functional limitations of no obviously advantage hemisphere and two hemisphere coordination while ADHD children were performing mental arithmetic,also hmitations in conflicting information processing,decision making,and more obviously in subtraction practice.