Clinical value of measurements of serum CEA,SCC and CYFRA21-1 levels before and after radiotherapy in patients with esophageal carcinoma / 国际检验医学杂志

ABSTRACT

Objective To study the changes of serum carcinoembryonic antigen (CEA ) ,squamous cell carcinoma related antigen (SCC) and cell keratin protein fragments-19(CYFRA21-1) levels before and after radiotherapy in the patients with esophageal car-cinoma .Methods Serum CEA ,SCC and CYFRA21-1 levels were measured in 80 patients with esophageal carcinoma before and af-ter radiotherapy as well as 30 healthy persons by the double-antibody sandwich ELISA .The detection results were compared .The serum CEA ,SCC and CYFRA21-1 levels were in the survival group and the dead group within 1 year were detected .Results The serum CEA ,SCC and CYFRA21-1 levels in the patients group were significantly higher than those in the control group ,the differ-ence was statistically significant (P< 0 .01) .The serum CEA ,SCC and CYFRA21-1 levels before radiotherapy were significantly higher than those after radiotherapy ,which in the dead group were significantly higher than those in the survival group ,the differ-ence was statistically significant (P<0 .05) .Conclusion Serum CEA ,SCC and CYFRA21-1 levels can provide reference for moni-toring and the curative judgement in the patients with esophageal carcinoma .