Relationship between adiponectin -11,377C > G Gene polymorphism and risk of coronary heart disease / 实用医学杂志
The Journal of Practical Medicine
;
(24): 2405-2407, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-455195
ABSTRACT
Objective To investigate the relationship between the polymorphism of adiponectin -11 ,377C> G gene and the risk of coronary heart disease(CHD). Methods A total of 126 CHD patients and 130 healthy controls were enrolled and the frequency of each genotypes and allele gene of adiponectin -11 ,377C > G were detected by polymerase chain reaction fragment length polymorphism (PCR-RFLP). Results (1) The adiponectin gene -11,377C > G sites existed gene polymorphism and the three genotypes were GG, CG and CC. (2) There was statistical difference between CHD group and control group; The G allele frequency of CHD group was significantly higher than that in control group (P G between acute coronary syndrome (ACS) group and stable angina group . ( 4 ) The risk of CHD were increased in CHD patients with G allele gene of adiponectin-11,377C > G (P G is associated with the increased risk of CHD. The increased G allele gene frequency may represent the increased risk of CHD.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Etiology study
/
Risk factors
Language:
Chinese
Journal:
The Journal of Practical Medicine
Year:
2014
Type:
Article
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