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Efficacy of Qijialifei capsule in adjuvant chemotherapy for retreatment patients with smear positive pulmonary tuberculosis / 中国医师进修杂志
Chinese Journal of Postgraduates of Medicine ; (36): 46-49, 2014.
Article in Chinese | WPRIM | ID: wpr-455473
ABSTRACT
Objective To evaluate the efficacy and safety of Qijialifei capsule,a kind of Chinese traditional medicine,as adjuvant chemotherapy for retreatment patients with smear positive pulmonary tuberculosis.Methods One hundred and sixty retreatment cases with smear positive pulmonary tuberculosis were divided into observation group (80 cases) and control group (80 cases).All patients received the therapy of 3SHRZE/6HRE.The patients in observation group took Qijialifei capsule.Then comparisons were made between two groups in the sputum tubercle bacillus conversion rate,focus improvement rate,cavity closing rate,the cellular immune function,and clinical symptom improvement.Results In 160 cases,77 cases in observation group and 78 cases in control group completed the treatment.At the end of intensified therapy period and at the end of the whole therapy the sputum tubercle bacillus conversion rate [79.2% (61/77),92.2% (71/77)] in observation group were significantly higher than those in control group [64.1% (50/78),78.2% (61/78)](P < 0.05).The focus improvement rate,cavity closing rate in observation group [74.0%(57/77),26.0%(20/77)] were significantly higher than those in control group [52.6% (41/78),11.5% (9/78)] (P < 0.05).At the end of intensified therapy period,the focus improvement rate,cavity closing rate in observation group [92.2% (71/77),54.5% (42/77)] were significandy higher than those in control group [76.9% (60/78),29.5% (23/78)] (P < 0.05).By the end of the whole therapy,the number of CD3+,CD4+,CD4+/CD8+ of patients in observation group were significantly higher than those in control group (P < 0.05).The disappearance of clinical symptoms in observation group was shorter than that in control group(P < 0.05).The rate of side effects on Qijialifei capsule was only 1.3%(1/77).Conclusions Qijialifei capsule can improve the cellular immune function of the patients,can effectively alleviate the symptoms and can improve the sputum tubercle bacillus conversion rate,radiographic focus improvement rate and cavity closing rate.It is safe.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Postgraduates of Medicine Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Postgraduates of Medicine Year: 2014 Type: Article