Study Progress in Methods and Mathematical Models for the Prediction of Drug Metabolism and Interac-tions on the Basis of in vitro Investigations / 中国药师

ABSTRACT

Objective: To provide the evidence for the development of new drugs, the modification in chemical structures of the registered drugs and the establishment of the therapeutic treatment involving several drugs. Method:Using cytochrome, drug interac-tion and in vitro investigations as the keywords, CHKD and PubMed were searched, and the corresponding references were summarized from 2003 to 2013. The biological characters of the cytochrome oxidase and the ways on the choice of the suitable enzyme system for the research of drug in vitro pharmacokinetic parameters were analyzed in order to predict the potential drug interactions in vivo. Result:The [I]/Ki value had close relation with the possibility of the potential interactions, however, the calculation of [I] was the difficult point, and the methods should be modified according to the specific situation. Conclusion:The prediction technology of drug metabo-lism and interactions on the basis of in vitro investigations can avoid the in vivo complicated process to the greatest extent, reduce the cycle time and the economic cost for the new drug development, and provide the logical evidence and the risky level for the reasonable application of clinical drugs.