Experimental Murine Fascioliasis Derives Early Immune Suppression with Increased Levels of TGF-beta and IL-4
The Korean Journal of Parasitology
;
: 301-308, 2012.
Article
in English
| WPRIM
| ID: wpr-45627
ABSTRACT
In fascioliasis, T-helper 2 (Th2) responses predominate, while little is known regarding early immune phenomenon. We herein analyzed early immunophenotype changes of BALB/c, C57BL/6, and C3H/He mice experimentally infected with 5 Fasciola hepatica metacercariae. A remarkable expansion of CD19+ B cells was observed as early as week 1 post-infection while CD4+/CD8+ T cells were down-regulated. Accumulation of Mac1+ cells with time after infection correlated well with splenomegaly of all mice strains tested. The expression of tumor necrosis factor (TNF)-alpha mRNA in splenocytes significantly decreased while that of IL-4 up-regulated. IL-1beta expression was down-modulated in BALB/c and C57BL/6 mice, but not in C3H/He. Serum levels of transforming growth factor (TGF)-beta were considerably elevated in all mice during 3 weeks of infection period. These collective results suggest that experimental murine fascioliasis might derive immune suppression with elevated levels of TGF-beta and IL-4 during the early stages of infection.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Spleen
/
B-Lymphocytes
/
CD4-Positive T-Lymphocytes
/
Down-Regulation
/
Immunophenotyping
/
Transforming Growth Factor beta
/
Immunosuppression Therapy
/
Interleukin-4
/
CD8-Positive T-Lymphocytes
/
Fasciola hepatica
Limits:
Animals
Language:
English
Journal:
The Korean Journal of Parasitology
Year:
2012
Type:
Article
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