Determination of Residual Solvent DMF in Imiquimod by HS-GC / 中国药师
China Pharmacist
;
(12): 1586-1588, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-456288
ABSTRACT
Objective:
To establish a new method for determining residual organic solvent DMF in imiquimod.Methods:
The samples were injected into an Agilent HP-PLOT/Q capillary column(30 m × 0. 530 mm,40. 0 μm) by a headspace sampler and ana-lyzed with an FID detector, the carrier gas was nitrogen, the inlet temperature was 250℃, and the detector temperature was 270℃. The column temperature was programmed raised.Results:
The resolution among the peaks of DMF and the other residual solvents could meet the requirements. There was a good linearity within the experimental concentration range. The average recovery was 94. 6%(RSD=4. 0%, n=9). The limit of quantification and the limit of detection was 4. 809μg·ml-1 and 0. 963μg·ml-1, respectively.Conclusion:
The method is convenient, accurate and sensitive, which can be used in the determination of residual solvent DMF in imi-quimod.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
China Pharmacist
Year:
2014
Type:
Article
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