Therapeutic effect and safety of amlodipine combined terazosin on middle and old aged male patients with essential hypertension / 心血管康复医学杂志

ABSTRACT

Objective:To observe the short-term therapeutic effect and safety of amlodipine combined terazosin on middle and old aged male patients with essential hypertension (EH).Methods:A total of 64 middle and old aged male EH patients treated in our hospital from Jan 2011 to Feb 2012 were enrolled.They were randomly and equally divided into amlodipine group and combined therapy group (received amlodipine combined terazosin treatment).Re-sultsTotal effective rate of combined therapy group (93.75%)was significantly higher than that of amlodipine group (65.63%),P =0.028;there were significant reductions in levels of systolic blood pressure (SBP),diastolic blood pressure (DBP),total cholesterol (TC),triglyceride (TG)and fasting plasma glucose (FPG)in both groups after treatment (P <0.05~<0.01),compared with amlodipine group,there were more significant reductions in these indexes [SBP(138.55±7.96)mmHg vs.(110.65±7.28)mmHg,DBP(93.35±5.86)mmHg vs.(80.11 ±5.93)mmHg,TC(5.67±0.76)mmol/L vs.(4.22±0.63)mmol/L,TG(2.67±0.86)mmol/L vs.(2.01± 0.75)mmol/L,FBG (5.69±0.86)mmol/L vs.(4.31±0.58)mmol/L]in combined therapy group,P <0.05 all;incidence rate of adverse reactions in combined therapy group (6.25%)was significantly lower than that of am-lodipine group (18.75%),P <0.05. Conclusion:Amlodipine combined terazosin possesses more therapeutic effect in middle and old aged male patients with essential hypertension.It can effectively reduce systolic and diastolic blood pressure;the adverse reactions are fewer,so it's worth extending in clinic.