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Serum metabonomics study on toxicity of Fructus Toosendan / 国际药学研究杂志
Article in Zh | WPRIM | ID: wpr-456408
Responsible library: WPRO
ABSTRACT
Objective 1H NMR spectroscopy and principal component analysis(PCA) were used to investigate the mouse serum metabonomics and toxic mechanism after oral administration of Fructus Toosendan. Methods In this study, mice were orally administered with the ethyl acetate extract of Fructus Toosendan before collecting serum samples. Then 1H NMR was utilized to identify the metabolites with the PCA. After the experimental model of toxicity was established and the data were collected, NMR spectral regions and the metabolites were identified and ranked according to their weight aline with the loading plot. Results The scores plot for classification within groups was clear and showed a great difference from the control group. Combining the body weight and biochemical results, the elevated levels of glucose, lactate, taurine, arginine, glycine and decreased levels of betaine, creatine, amino and neurotransmitters were observed. Conclusion Our current study indicated that the ethyl acetate extract of Fructus Toosendan has liver and kidney toxicity.
Key words
Full text: 1 Index: WPRIM Type of study: Prognostic_studies Language: Zh Journal: Journal of International Pharmaceutical Research Year: 2014 Type: Article
Full text: 1 Index: WPRIM Type of study: Prognostic_studies Language: Zh Journal: Journal of International Pharmaceutical Research Year: 2014 Type: Article