Epigenetic regulation of androgen receptors in prostate cancer / 中国肿瘤临床
Chinese Journal of Clinical Oncology ; (24): 1057-1060, 2014.
Article in Chinese | WPRIM | ID: wpr-456495
Responsible library: WPRO
ABSTRACTThe androgen receptor (AR), a nuclear hormone and transcription factor, is the most therapeutic relevant target in pros-tate cancer (PCa) and in the castration-resistant prostate cancer (CRPC). Significant efforts have been focused on understanding the mechanisms involved in the development and progression of CRPC. Recent work has revealed the importance of epigenetic events in-cluding the regulation of AR signaling by methylation, acetylation, and non-coding RNA in the tumorigenesis and development of PCa. We summarize recent findings on the mechanisms of epigenetic regulation of AR signaling in PCa.
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Clinical Oncology Year: 2014 Type: Article