The application of vitamin D in essential hypertension treatment / 国际检验医学杂志

ABSTRACT

Objective To investigate the standard supplement of a certain dose of vitamin D for blood pressure control in pa-tients with essential hypertension.Methods 100 cases of patients with essential hypertension were randomly divided into 2 groups voluntarily,50 cases in each group.One group were set as control group,in which patients underwent a standard treatment.The other group was experimental group,in which 25 μg/d vitamin D was administrated in addition to standard treatment.Serum 25-hydroxyvitamin D[25 (OH)D]concentrations were measured by enzyme-linked immunosorbent assay(ELISA)and patients were followed up for one year to observe the situation of blood pressure controll.Mean and variable coefficient(CV)of systolic and dias-tolic blood pressure were calculated and compared between groups.Results In experiment group,the serum 25 (OH)D concentra-tion was (110.3±24.5)μg/L,systolic pressure was (144±16)mm Hg,variable coefficient of systolic pressure(CV1)was 11.1%, diastolic pressure was (87±9)mm Hg,variable coefficient of diastolic pressure(CV2)was 10.3%.While in control group,the 25 (OH)D concentration was (30.1±14.9)μg/L,systolic pressure was (145 ±26)mm Hg,CV1 was 17.9%,diastolic pressure was (87±10)mm Hg,CV2 was 12.4%.Serum 25(OH)D concentration and CV1 were statistically different between the two groups(P0.05).Conclusion Administrate quantitative vitamin D in addition to standard treat-ment is helpful for systolic pressure control in patients with essential hypertension but is meaningless for diastolic pressure control.