Effects of Instant Hyperbaric Oxygen Therapy on Brain Edema and Expression of Aquaporin-4 after Cerebral Ischemia in Rats / 中国康复理论与实践

ABSTRACT

Objective To observe the effects of instant hyperbaric oxygen (HBO) therapy on brain edema and aquaporin-4 (AQP4) ex-pression after cerebral ischemia in rats. Methods 18 healthy adult male Sprague-Dawley rats were randomly divided into sham group (n=6), control group (n=6) and HBO group (n=6). Middle cerebral artery occlusion model was established with modified Longa method in the con-trol group and HBO group. HBO was administered after cerebral ischemia immediately in HBO group for 60 min. They were observed with the neurological function score, brain tissue water content and AQP4 experssion 6 h after operation. Results Compared with the control group, the neurological score in HBO group improved significantly (P<0.05), while the brain tissue water content and brain AQP4 expres-sion decreased (P<0.05). Conclusion HBO may improve the neurological function and brain edema after cerebral ischemia, which may re-late with inhibiting the expression of AQP4.