Bone Induction by Demineralized Dentin Matrix in Nude Mouse Muscles / 대한악안면성형재건외과학회지
Maxillofacial Plastic and Reconstructive Surgery
;
: 50-56, 2014.
Article
in English
| WPRIM
| ID: wpr-45746
ABSTRACT
PURPOSE:
This study examined the osteoinductive activity of demineralized human dentin matrix for nude mice.METHODS:
Twenty healthy nude mice weighing about 15 to 20 g were used for study. Demineralized human dentin matrix was prepared and implanted into the dorsal portion of nude mice (subcutaneous), which were sacrificed at two, four, and eight weeks after demineralized dentin matrix grafting and evaluated histologically by H&E and Masson trichrome staining. The specimens were also evaluated histomorphometrically.RESULTS:
The demineralized dentin matrix induced bone and cartilage formation independently in soft tissues. Histological examination showed bone-forming cells such as osteoblasts and fibroblasts at two, four, and eight weeks.CONCLUSION:
These results suggest that demineralized human dentin matrix has osteoinductive ability, and is a good alternative to autogenous bone graft materials.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Osteoblasts
/
Cartilage
/
Transplants
/
Dentin
/
Fibroblasts
/
Mice, Nude
/
Muscles
Limits:
Animals
/
Humans
Language:
English
Journal:
Maxillofacial Plastic and Reconstructive Surgery
Year:
2014
Type:
Article
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