Role of serum and urine NGAL in assessment of renal function in patients with primary hypertension / 中国免疫学杂志
Chinese Journal of Immunology
;
(12): 1672-1675, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-457543
ABSTRACT
Objective:
to investigate clinical significance of serum and urine NGAL (Neutrophil gelatinase-associated lipocalin) in the early kidney damage with primary hypertension.Methods:
According to UAER ( urinary microalbumin excreting rate ) ,we divided 90 patients with primary hypertension into three groups (300 mg/24h),and selected 30 healthy people as the control group.Serum and urine NGAL and cystatin C ,serum creatinine,urea nitrogen,high sensitive C reactive protein , transferrin,and basis of blood pressure were detected and followed up one year.Results:
Compared with healthy group ,GFR( glomerular filtration rate ) and serum NGAL were decreased significantly in medium and severe proteinuria groups , while urine NGAL was increased.Conclusion:
Serum and urine NGAL have been a clear trend changes in kidney damage ,which could be used as a reliable indicator in monitoring renal function of patients with primary hypertension.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Immunology
Year:
2014
Type:
Article
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