Clinical research of patients with ovulation obstructive infertility by combined treatment of stimulating ovulation particles and clmiphene citrateclinical / 实用医学杂志

ABSTRACT

Objective To observe the clinical curative effect of patients with ovulation obstructive infertility by combined treatmentofstimulating ovulation particles and clmiphene citrateclinical. Methods 171 patients were randomly divided into Traditional Chinese medicine (TCM) group (42 cases), clmiphene citrateclinical (CC) group (53 cases) andcombined treatment of TCM and CC group (76 cases). Ultrasound examinations were used to monitor the development of endometrium, follicular development and value of Plusatility Index (PI). The levels of E2,LH and P were measured before and after medication. And pregnancy of patients was followed up. Results Ovulation rates of combined treatment of TCM and CC group and the CC group were both higher than TCM group (P<0.05). Pregnancy rate of combined treatment of TCM and CC group was higher than TCM group and CC group (P<0.05). Endometrial thickness and type A lining rate of combined treatment of TCM and CC groupandTCM group were both higher than CC group (P < 0.05). The values of PI of combined treatment of TCM and CC groupand TCMgroup were both lower than CC group on HCG day after treatment (P<0.05). E2 values ofpost-treatment of three groups were all significantly higher than that before treatment.Difference in values of E2 and LH between pretherapy and post-treatment of combined treatment of TCM and CCwere obviously higher than that of TCM group (P<0.05).Difference in values of P between pretherapy and post-treatment of tcombined treatment of TCM and CC and TCM group were higher than CC group on the seventh day after ovulation (P < 0.05). Conclusions Combination of traditional Chinese medicine and CCcouldnot only promote follicle growth , but also improve anti-estrogen role of CC , endometrial blood flow and endocrine regulation , enhance ovulation rate and decrease the rate of abortion. Ovulation obstructive infertility treatment was better than that of CC and TCM treatment.