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Research Advances on Triterpenoid Saponins Biosynthesis and Its Key Enzymes / 世界科学技术-中医药现代化
Article in Chinese | WPRIM | ID: wpr-457615
Responsible library: WPRO
ABSTRACT
As an important kind of plant secondary metabolites and widely distributed in the plant kingdom, triter-penoid saponins have a variety of biological activities. The constitution and content of triterpenoid saponin are deter-mined by some key enzymes and their expressing level in triterpenoid saponins biosynthesis pathway. So, it is very important to illuminate the molecular mechanism of triterpenoid saponins biosynthetic pathway. In recent years, illu-mination of the entire biosynthetic pathway especially the confirmation and cloning of the key enzymes, such as squa-lene synthase, squalene epoxidase, cytochrome P450 monooxygenase and UDP-glycosyltransferase, had become one of the hot spots by many scholars. In this paper, the entire biosynthetic pathway and some kinds of key enzymes in-volved in the synthesis of carbon skeleton, and its oxidation, and glycation were reviewed for further demonstrating the biosynthetic pathway of triterpenoid saponins and providing a theoretical basis for artificial biosynthesis.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: World Science and Technology-Modernization of Traditional Chinese Medicine Year: 2014 Type: Article
Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: World Science and Technology-Modernization of Traditional Chinese Medicine Year: 2014 Type: Article