AMPK/mTOR pathway and leucine resistance in sepsis / 医学研究生学报
Journal of Medical Postgraduates
;
(12): 1311-1314, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-458020
ABSTRACT
Sepsis leads to inhibition of protein synthesis , known as leucine resistance .mTOR regulates protein synthesis by phosphorylation of S6K1 and 4E-BP1.AMPK is an important negative regulator of mTOR and its activity is in an abnormal state in sep-sis.This review briefly discusses the AMPK/mTOR pathway in Sepsis-induced leucine resistance .
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Medical Postgraduates
Year:
2014
Type:
Article
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