The effects of dexmedetomidine and ketamine on breast lumpectomy in women patients / 重庆医学

ABSTRACT

Objective To observe the effects of dexmedetomidine and ketamine on breast lumpectomy in women patients .Meth‐ods Thirty women who underwent breast lumpectomy were randomly allocated into two groups (n=15) .Group A received mid‐azolam 2 .0 mg ,fentanyl 0 .1 mg and ketamine 2 .0 mg/kg ,everyone required supplementary propofol 5 .0 mg?kg -1 ?h-1 .In group B ,dexmedetomidine 0 .5 μg/kg was administered as a loading dose during 10 minutes followed by a continuous infusion of 0 .2μg?kg -1 ?h-1 ,Ketamine 2 .0 mg/kg was administered along with the dexmedetomidine loading dose .The recovery time ,the VAS and Ramsay at the end of the first hour of postoperation were recorded along with side effects .Meanwhile ,hemodynamic parameters , like heart rate(HR) ,mean blood pressure (MAP) and SPO2 were also monitored .Results Compared with group A ,the HR and MAP were significantly lower(P0 .05) in group B;there was no sig‐nificant difference in VAS and Ramsay scores among two groups ,the recovery time was shorter in group B(P<0 .05) .However ,the incidence of respiratory arrest and glossocoma were greatly higher in group A(P<0 .05) .Conclusion Dexmedetomidine and ket‐amine can offer an effective sedoanalgesia and lower hemodynamic discrepancy without causing any significant side effect on breast lumpectomy in women patients .