Expression and clinical significance of serum microRNA-100 in gastric cancer patients / 中国肿瘤临床
Chinese Journal of Clinical Oncology
;
(24): 1587-1590, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-458193
ABSTRACT
Objective:
To investigate the expression of microRNA-100 (miR-100) in the serum of gastric cancer patients and its clinical significance.Methods:
At The First Affiliated Hospital of Bengbu Medical College, 40 gastric cancer patients who underwent surgery with complete follow-up data and 40 healthy controls were selected as research subjects. Total miRNA was isolated from the se-rum samples of the cancer patients. A stable and sensitive detection method for the absolute quantification of miR-100 was established. The serum levels of miR-100 in the patients and healthy controls were tested according to this novel method. Differences of the miR-100 expression in the serum samples of the patients and healthy controls were analyzed using statistical analysis. The correlation between miR-100 expression levels and the clinicopathological features of gastric cancer was also analyzed.Results:
The expression level of miR-100 in the serum was significantly higher in cancer patients[(2.78±1.92) fmol/L]than in the healthy controls[(0.19± 0.15) fmol/L, P0.05).Conclusion:
Serum miR-100 testing may be helpful in the diag-nosis of gastric cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Chinese Journal of Clinical Oncology
Year:
2014
Type:
Article
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