Correlation between pulmonary quantitative indicators on high-resolution CT and pulmonary function in patients with chronic obstructive pulmonary disease / 中国基层医药

ABSTRACT

Objective To study the relationship between pulmonary quantitative indicators on 64-slice spiral CT and lung function,and the diagnosis value of breathing bipolar lung CT scan to emphysema.Methods 54 chronic obstructive pulmonary disease patients were divided into the mild group ( n =5 ) , moderate group ( n =21 ) , severe group(n=19) and gravely severe group(n=9).Four groups received breathing bipolar total lung high-resolution CT scan to test lung density at the end of deep inspiration and expiration,breathing bipolar lung density difference and lung volume,and the relationship between lung density/volume and lung function indicators were analyzed.Results There were significant differences in lung density at the end of deep inspiration and expiration(t=13.67,9.89,all P0.05).The lung volumes at the end of deep inspiration and expiration were obvi-ously correlated with FVC,FEV1 and FEV1/FVC(r=-0.071,-0.083,r=-0.713,-0.542,r=-0.622,0.639, all P<0.05) .The lung volume at the end of deep expiration was obviously correlated with the expected ratio of resid-ual volume to maximum total lung capacity(r=0.622,P<0.05).The deep aspiratory phase lung density was closely correlated with FEV1/FVC and residual volume(r=0.539,P<0.05).Conclusion Pulmonary quantitative indica-tors on 64-slice spiral CT and pulmonary function has good correlation,which can be used to evaluate the severity of emphysema in patients with chronic obstructive pulmonary disease.