Vitreous Vascular Endothelial Growth Factor Concentration In Various Vitreoretinal Disorders
Journal of the Korean Ophthalmological Society
;
: 96-103, 2002.
Article
in Korean
| WPRIM
| ID: wpr-45853
ABSTRACT
PURPOSE:
Vascular endothelial growth factor (VEGF) has been identified as an endothelial cell-specific angiogenic factor of intraocular neovascularization, a pathologic complication of many vitreoretinal disorders. We studied to evaluate clinical correlation of intravitreal VEGF concentration and various vitreoretinal disorders.METHODS:
Forty eight vitreous fluid samples were obtained at the time of vitreoretinal surgery from 43 patients of various disorders. Concentrations of VEGF1 6 5 in vitreous fluid were determined by Human VEGF ELISA kit and its correlation with diabetes, intraocular hemorrhage, neovascularization, proliferative vitreoretinopathy, retinal detachment, pan retinal photocoagulation, and postoperative condition was statistically analyzed.RESULTS:
Intravitreal concentrations of VEGF in case of intraocular hemorrhage (0.809+/-1.467 ng/ml), neovascularization (1.167+/-1.656 ng/ml), and anterior segment neovascularization (2.381+/-2.043 ng/ml) were significantly high (P<0.05).CONCLUSIONS:
VEGF plays a major role in the development of neovascularization in the various retinal disorders.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Retinaldehyde
/
Retinal Detachment
/
Enzyme-Linked Immunosorbent Assay
/
Vitreoretinopathy, Proliferative
/
Vascular Endothelial Growth Factor A
/
Angiogenesis Inducing Agents
/
Vitreoretinal Surgery
/
Hemorrhage
/
Light Coagulation
Type of study:
Prognostic study
Limits:
Humans
Language:
Korean
Journal:
Journal of the Korean Ophthalmological Society
Year:
2002
Type:
Article
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