Resistant mechanism about rapamycin and solution / 国际肿瘤学杂志
Journal of International Oncology
;
(12): 740-743, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-459021
ABSTRACT
mTOR signaling pathway is closely related to cell proliferation,cell cycle and other pathological processes about tumor.Rapamycin plays an anti-tumor effect through inhibiting mTOR,but it prone to drug resistance,which leads to limited clinical application.Its resistant mechanism is related with the activation of PI3K-Akt,which is regulated with negative feedback.Dual inhibitors of related proteins of mTOR pathway are expected to reverse the drug resistance.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of International Oncology
Year:
2014
Type:
Article
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