Blood coagulation function changes and intervention effects of metformin in patients with impaired glucose tolerance / 中国医师进修杂志

ABSTRACT

Objective To investigate the blood coagulation function changes and intervention effects of metformin in patients with impaired glucose tolerance.Methods One hundred patients with impaired glucose tolerance and 50 healthy volunteers (control group) were recruited.The patients with impaired glucose tolerance were divided into test group 1 and test group 2 by random digits table method.The patients in test group 2 were given metformin and the patients in test group 1 were given the same dosage of placebo.The oral glucose tolerance test (OGTT),glycosylated hemoglobin (HbA1c),prothrombin time (PT),activated partial thromboplastin time (APTT),thrombin time (TT) and fibrinogen (Fib) level were determined before and after treatment.Results Compared with those in control group,the patients in test group 1 and test group 2 had higher level of 2 h postprandial blood glucose (2 h PBG),HbA1c and Fib,and lower level of APTT,PT (P ＜ 0.05).The level of 2 h PBG,HbA1c and Fib in test group 2 were significantly lower than those in test group 1,(6.6 ± 2.5) mmol/L vs.(7.9 ± 3.6) mmol/L,(5.2 ± 1.3)％ vs.(5.8 ± 1.4)％,(3.0 ± 1.0) g/L vs.(3.6 ± 1.2) g/L,and the level of APTT and PT were significantly higher than those in test group 1,(34.3 ± 6.8) s vs.(31.6 ± 6.5) s,(12.6 ± 0.7) s vs.(12.3 ± 0.7) s,P ＜ 0.05.Compared with those in control group,there were no significant differences (P ＞ 0.05).Pearson line correlation analysis revealed that APTT and PT had negative correlation with 2 h PBG and HbA1c (P ＜ 0.01),and Fib had positive correlation with 2 h PBG and HbA1c (P ＜ 0.01).TT had no correlation with 2 h PBG and HbA1c (P ＞ 0.05).Conclusion Blood coagulation function of patients with impaired glucose tolerance may have some alteration,and appropriate therapeutic intervention can reduce the risk factors for cardiovascular disease.