Effect of motivation of EPCs by G-CSF on cardiac function in patients with myocardial infarction / 实用医学杂志

ABSTRACT

Objective To observe the effect of motivation of endothelial progenitor cells (EPCs) by granulocyte colony-stimulating factor (G-CSF) on cardiac function in patients with myocardial infarction (MI). Methods Eighty MI patients were sellectedand then were divided into a conventional treatment group (n = 40) and a EPC motivation group (n = 40). EPCs were detected by flow cytometry. Results The rate of EPCs was increased from (0.11 ± 0.04)% in the baseline to (5.32 ± 1.06)% (P 0.05); after treatment, 6MWT, LVEF, and LVEDD were significantly increased in both groups (P 0.05). Conclusions G-CSF can markedly motivate EPCs, which is beneficial for improvement of cardiac function in MI patients.