FSCN1 mRNA expression in breast carcinoma and benign breast diseases / 实用医学杂志

ABSTRACT

Objective To investigate the expression of FSCN1 mRNA in breast carcinoma and benign breast diseases and its relationship to clinicopathological characteristics of breast cancer. Methods Sixty-three cases of breast cancer and thirty cases of benign breast diseases were analyzed by in situ hybridization. Results The expression rates of FSCN1 mRNA in breast cancer tissue and benign breast lesions were 65.1% and 90.0% , respectively (P < 0.05). No relation was found between the expression of FSCN1 mRNA and histopathologic grading, ER, PR, karyokinesis figure, patients′ age, tumor size, lymph node metastasis, TNM stage and c-erbB-2 expression in breast cancer. Survival rates of breast cancer patients with carcinoma expressing FSCN1 mRNA were 92.3% , while those patients with tumors which was negative for FSCN1 mRNA were 82.2%, but there was no significance difference. A significant correlation was observed between FSCN1 mRNA and its protein expression (rs = 0.315, P < 0.05). Conclusion FSCN1 is downregulated in breast carcinoma which may be associated with breast carcinogenesis.