Preliminary study on the efficacy and safety of levtiracetam in infant with epilepsy / 重庆医学

ABSTRACT

Objective To preliminary evaluate the efficacy and safety of Lev therapy in infant with epilepsy .Methods To chil-dren with infant epilepsy in the Department of Neurology of Chongqing Children′s Hospital from May 2010 to February 2012 were enrolled .All of them took Lev mono-therapy or adjunctive therapy .Investigation was done by self-controlled and retrospective re-search .There were 70 patients received Lev therapy ,aging from one month to one year old ,and 39 patients received mono-therapy , 31 patients received adjunctive therapy .All subjects were divided into 2 groups ,12 patients in partial seizure group and 58 patients in generalized seizure group .Then all patients took a 7 months Lev therapy after initial medication .The seizure frequency change , seizure situation ,side effect were observed .Results During the follow-up ,5 patients lost their follow-up(3 case in mono-therapy group ,2 case in adjunctive therapy group)and 3 patients died .In mono-therapy group ,83 .33% of patients got responder and 16 . 67% of patients unmodified or worsen ,while those in adjunctive therapy group were 58 .62% and 41 .38% ,respectively .And there was significant difference between two groups(P0 .05) .During the study ,22 patients ended Lev therapy for some reasons .77 .27% of patients discontinued in 1-6 months and 22 .73% of patients in 7-34 months .Number of the adverse reac-tions was 14 .Main adverse reactions observed were anorexia and sleep disorders in early .3(4 .61% )of 65 patients discontinued ther-apies for the adverse reaction ,but there was no death caused by adverse reaction .Conclusion The Lev mono-therapy and adjunctive therapy are both effective in infant with epilepsy ,and Lev therapy is effective in infant epilepsy .