Research progress in aberrant sphingolipid metabolism and obesity and obesity-mediated insulin resistance / 医学研究生学报

ABSTRACT

Sphingolipids are essential components of cellular membrane , regulating important physiologic function of cells .Al-terations of sphingolipid metabolism are closely related to the pathogenesis of several chronic diseases .Ceramide biogenesis , the center of sphingolipid metabolism , includes de novo ceramide synthesis , ceramide formation via breakdown of complicated sphingolipids and so on . Recent studies found that aberrant sphingolipid metabolism is strongly linked to insulin resistance associated with obesity .The review fo-cuses on recent advances about aberrant sphingolipid metabolism in the pathogenesis of insulin resistance associated with obesity .