Clinical trial of electronic antiemetic acupuncture in combination with palonosetron in prevention of tardive vomiting induced by highly emetogenic chemotherapy / 重庆医学

ABSTRACT

Objective To explore the effect of electronic antiemetic acupuncture in combination with palonosetron in preven‐ting tardive vomiting induced by highly emetogenic chemotherapy for cancer patients .Methods One hundred and twenty cancer pa‐tients undergoing highly emetogenic chemotherapy were divided into observation group and control group(n=60) .The observation group was treated with electronic antiemetic acupuncture in combination with palonosetron and the control group was treated with palonosetron .The different effects against nausea and vomiting between these two groups were evaluated after 24 hours of the chemotherapy .Results Response rate of improvement of nausea for the observation group and control group from the 2nd day to the 8th day were 90 .0% vs 71 .7% ,68 .3% vs 41 .7% ,60 .0% vs 36 .7% ,65 .0% vs 40 .0% ,80 .0% vs 58 .3% ,91 .7% vs 81 .7% , 98 .3% vs 96 .6% .From the 2nd day to the 6th day there were statistical difference of the two groups(P0 .05) .Response rate of prevention of vomit for the observation group and control group from the 2nd day to the 6th day were 98 .3% vs 88 .3% , 81 .7% vs 65 .0% ,75 .0% vs 51 .7% ,90 .0% vs 70 .0% ,98 .3% vs 88 .3% ,and there were statistical difference of the two groups (P<0 .05) .The prevention of vomiting in the 7th day and 8th day of the two groups were 98 .3% vs 86 .7% ,98 .3% vs 88 .3% , there were also statistical difference(P<0 .05) .Conclusion The treatment of electronic antiemetic acupuncture in combination with palonosetron have greater effect in prevention of tardive vomiting than palonosetron caused by highly emetogenic chemotherapy .It can be used conventionally in the chemotherapy .