Effect of serum inflammatory cytokine by adjuvant minocycline ointment in the treatment of aggressive periodontitis / 重庆医学

ABSTRACT

Objective To investigate the changes of serum C reactive protein(CRP) ,tumor necrosis factor alpha(TNF-alpha) and interleukin-17(IL-17) by minocycline ointment on the basis of conventional therapy in the treatment of aggressive periodontitis (AgP) .Methods All 45 cases of AgP patients were randomly divided into two groups ,23 cases in the therapeutic group ,were per-formed scaling and root planning plus local minocycline hydrochloride Ointment medication;22 cases in the control group ,were trea-ted by scaling and root planing only .All aggressive periodontitis patients were detected the serum CRP ,TNF-alpha and IL-17 levels before and after treatment ,and compared with normal controls .Results The serum levels of CRP ,TNF-αand IL-17 in normal hu-man were lower than those of AgP patients before and after treatment(P<0 .05) .After 3 months treatment ,the serum levels of CRP ,TNF-αand IL-17 in AgP patients were significantly lower than those before treatment(P<0 .05) .Conclusion The effect of minocycline on the basis of conventional therapy in the treatment of AgP patient is remarkable ,which can improve the serum level of CRP ,TNF-alpha and IL-17 .