Application and research of cTnI and NT-proBNP in efficacy evaluation of thrombus aspiration / 国际检验医学杂志

ABSTRACT

Objective To investigate the effect of thrombus aspiration on troponin I (cTnI) and N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) in the patients with acute myocardial infarction .Methods According to whether performing the thrombus aspiration therapy ,106 patients with acute myocardial infarction were divided the thrombus aspiration group (51 cases) and the di‐rect stenting group (55 cases) .The changes of cTnI and NT‐proBNP before and after treatment were compared between the two groups ,at the same time the occurrence rates of complications and postoperative cardiovascular events were also compared between the two groups .Results Compared with the stenting group ,the cTnI peak time in the aspiration group was in advance[(10 .2 ± 2 .9)h vs .(18 .3 ± 3 .6)h ,P< 0 .05] ;the peak value of cTnI in the aspiration group was decreased ,the differences had statistical sig‐nificance[(21 .9 ± 8 .8) ng/mL vs .(40 .3 ± 11 .8)ng/mL ,P< 0 .05] .The preoperative NT‐proBNP level in the two groups were in‐creased ,the NT‐proBNP level on postoperative 1 d in the aspiration group was lower than that in the stenting group with statistical difference[(7 084 .6 ± 735 .2) pg/mL vs .(14 109 .7 ± 849 .1) pg/mL ,P< 0 .05)] .5 cases of slow blood flow occurred in the stent‐ing group ,no case of slow blood flow or no blood flow phenomenon occurred in the aspiration group ,the difference was statistically significant(P< 0 .05) .After half a year of follow‐up ,4 cases of heart failure in the stenting group and 1 cases of heart failure in the aspiration group occurred ,the difference was statistically significant(P < 0 .05) .Conclusion The thrombus aspiration can reduce the occurrence of slow blood flow or no blood flow phenomenon in the interventional therapy ,cTnI and NT‐proBNP dynamic detec‐tion can provide the basis for judging the prognosis .