Cord blood Cytokines on the Development of Cerebral Palsy in Premature Infant / 소아과
Korean Journal of Pediatrics
; : 1293-1299, 2004.
Article
in Ko
| WPRIM
| ID: wpr-46070
Responsible library:
WPRO
ABSTRACT
PURPOSE: This study was performed to determine the relation between cord blood plasma cytokines responses and development of cerebral palsies in premature infants. METHODS: Interleukin-1beta(IL-1beta), Interleukin-6(IL-6), Tumor necrosis factor-alpha(TNF-alpha) were measured using ELISA kits in premature infants(n=60) who were admitted to St. Benedict Hospital from September 2001 to June 2003. Retrospective study was done by review of medical records. RESULTS: Cord blood levels of IL-1beta, IL-6 and TNF-alpha in the cerebral palsy group were higher, especially IL-6 but were not significant, compared with the control group. Cord blood levels of IL-6 in the cerebral palsy without asphyxia, sepsis, PROM, RDS and pneumonia were significantly different, compared with the control group. CONCLUSION: Cord blood levels of IL-1beta, IL-6 and TNF-alpha in the cerebral palsy group were increased, but concentrations of IL-6 increased significantly. Cord blood levels of IL-6 may be a useful value to predict the development of cerebral palsy, because they are related to IL-6 rather than to TNF-alpha & IL-1beta in this study.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Paralysis
/
Plasma
/
Pneumonia
/
Asphyxia
/
Infant, Premature
/
Enzyme-Linked Immunosorbent Assay
/
Cerebral Palsy
/
Medical Records
/
Retrospective Studies
/
Cytokines
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Humans
/
Newborn
Language:
Ko
Journal:
Korean Journal of Pediatrics
Year:
2004
Type:
Article