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The role of 11β-HSD1 in metabolic syndrome / 中国糖尿病杂志
Chinese Journal of Diabetes ; (12): 378-380, 2015.
Article in Chinese | WPRIM | ID: wpr-460781
ABSTRACT
[Summary] MS ,which is highly related tothe occurrence of cardiovascular disease and T2DM ,is characterized by glucose and fat metabolic dysregulation ,central obesity ,hypertension and hyperuricemia.11β‐hydroxysteroid dehydrogenase type 1 (11β‐HSD1) is regarded as a new therapeutic target for MS.11β‐HSD1 converts inactive glucocorticoid to active glucocorticoid. 11β‐HSD1 knockout improves obesity , hyperlipidemia andhyperglycemia. The inhibition of 11β‐HSD1 alleviates IR in human and rodents ,but the application of 11β‐HSD1 inhibitors is limited by the side effects.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Diabetes Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Diabetes Year: 2015 Type: Article