Effect of dexmedetomidine on serum TNF-αand IL-6 in neurosurgical patients during perioperation period and its clinical observation / 中国生化药物杂志

ABSTRACT

Objective To observe the effects of dexmedetomidine on serum TNF-αand IL-6 in neurosurgical patients during perioperative period. Methods 60 cases patients with intracranial aneurysm treated in our hospital in January 2014 to August 2014 were selected as the research objects, and they were randomly divided into two groups with 30 cases in each group.Before induction, the observation group adopted 1μg/kg dexmedetomidine with 10 min infusion, then adopted 0.4μg/( kg? h) infusion of dexmedetomidine, and control group received saline infusion.Serum TNF-αand IL-6 levels in two groups were compared at different time.Results After application of dexmedetomidine, the related indexes of hemodynamics in observation group, mean arterial pressure (MAP) and heart rate (HR) were more stable (P<0.05).Serum levels of TNF-αat the time of after induction, skin incision operation, 1h operation in observation group were (1.32 ±0.35), (1.42 ±0.54), (1.52 ±0.67), (1.57 ±0.63) μg/L, and were lower than those of control group, respectively (P<0.05).Serum levels of IL-6 at the time of after induction, skin incision operation, 1h operation in observation group were (69.64 ±13.54), (72.43 ±16.75), (76.32 ±16.93), (77.42 ±15.75) μg/L and were lower than those of control group, respectively (P<0.05).Conclusion The hemodynamics after application of dexmedetomidine in patients with neurosurgery operation is more stable, and the serum TNF-αand IL-6 are lower, so it contributes to the anti-inflammatory and has important clinical value.