Application of continuous blood purification in children with severe sepsis / 中华实用儿科临床杂志

ABSTRACT

The mechanism of sepsis is complicated,currently the treatment of severe sepsis is still a challenge.When infected,the body would release cytokines and inflammatory mediators,resulting in out of control of inflammatory reaction and disorder of immune system.Furthermore,sepsis and severe sepsis will be developed.The technique of continuous blood purification (CBP)can powerfully clear solute as water,metabolic wastes,toxic substances,cytokines and inflammatory mediators.Now this technique is not only applied in renal disorders,but also widely used in rescue treatment for critically ill patients.Recently,the guide of sepsis recommended CBP as a method of treating severe sepsis.With CBP application in the early stage of children severe sepsis,it can improve function of heart and lung function,renal function,immune function,coagulation function,and etc.CBP is becoming more and more important in the treatment of children severe sepsis.There are some remaining problem to be resolved,and the individaulized treatment for children sepsis is the focus in the future study.