Changes of serum Hcy,M-CSF,UA,platelet related indexes and trace element levels in CHD patients with angina pectoris / 心血管康复医学杂志

ABSTRACT

Objective:To observe the change of serum homocysteine (Hcy),macrophage colony stimulating factor (M-CSF),uric acid (UA),platelet related indexes and trace element levels in coronary heart disease (CHD)pa-tients with angina pectoris.Methods:A total of 58 CHD patients with angina pectoris treated in our hospital from Oct 2010 to Oct 2013 were selected as angina pectoris group,another 58 healthy subjects in same period were en-rolled as healthy control group.Levels of Hcy,M-CSF,UA,platelet related indexes [platelet distribution width (PDW),CD61,CD63]and trace elements were compared between angina pectoris group and healthy control group.Results:Compared with healthy control group,there were significant rise in serum levels of platelet related indexes,Hcy,M-CSF,UA,Zn and Fe,and significant reduction in serum Mn level in angina pectoris group,P <0.05 all;compared with patients with stable angina pectoris,there were significant rise in serum levels of PDW [(13.37±1.61)vs.(17.86±1.99)],CD61 [(45.26±5.11)vs.(58.40±7.20)],CD63 [(14.05±1.96)vs. (18.78±2.95)],Hcy [(13.47±1.52)mmol/L vs.(21.96±2.23)mmol/L],M-CSF [(289.73±31.68)pg/ml vs. (401.56±48.96)pg/ml],UA [(287.95±36.49)μmol/L vs.(373.45±45.26)μmol/L],Zn [(15.76± 1.84)μmol/L vs.(19.55±1.98)μmol/L]and Fe [(12.68±1.50)mmol/L vs.(15.71±1.83)mmol/L],and significant reduction in serum Mn level [(2.21±0.34)μmol/L vs.(1.60±0.21)μmol/L]in patients with unstable angina pec-toris (P <0.05 all).Along with number of coronary diseased vessels increased,serum levels of above indexes signifi-cantly rose except serum Mn level,P <0.05 all.Conclusion:The serum Hcy,M-CSF,UA,platelet related indexes and most trace elements levels significantly rise in CHD patients with angina pectoris,and the abnormal degree is greatly influenced by the angina pectoris type and number of coronary diseased vessels.