Influence of resveratrol on blood lipid level and ADRP expression in atherosclerosis model rabbits / 心血管康复医学杂志

ABSTRACT

Objective:To explore the influence of resveratrol on blood lipid level and expression of adipose differenti-ation related protein (ADRP)in atherosclerosis (AS)model rabbits.Methods:A total of 36 New Zealand rabbits were randomly and equally divided into normal control group,AS model group,low dose resveratrol group (low dose group)and high dose resveratrol group (high dose group).Rabbits received 15-week administration,expression level of serum lipoprotein,ADRP and ADRPmRNA expressions in adipocytes of rabbit aortic tissue were measured and compared among all groups before and after treatment.Results:Compared with AS model group at the end of 15th week,there were significant reductions in serum concentrations of total cholesterol [TC,(18.25±4.35)mmol/L vs.(12.79±2.45)mmol/L,(10.35±2.80)mmol/L],triglyceride [TG, (3.15±0.94)mmol/L vs. (2.63± 0.75)mmol/L、(1.18±0.64)mmol/L]and low density lipoprotein cholesterol [LDL-C,(15.18±3.65)mmol/L vs.(8.35±1.15)mmol/L,(7.18±1.75)mmol/L],and significant rise in level of high density lipoprotein choles-terol [HDL-C,(1.02±0.36)mmol/L vs.(3.22±1.02)mmol/L,(2.72±0.82)mmol/L]in low dose group and high dose group (P <0.05 or <0.01),and significant reduction in level of triglyceride [TG,(3.15±0.94)mmol/L vs.(1.18±0.64)mmol/L]in high dose group,P <0.01;ADRP histochemical staining [(0.43±0.05)vs.(0.35± 0.04),(0.38±0.15)]and ADRPmRNA expression [(2.47±0.94)vs.(1.30±0.49),(1.83±0.61)]significantly weakened in adipocytes of aortic tissue in low dose group and high dose group,P <0.01 all. Conclusion:Resveratrol can inhibit the overexpression of ADRP and its mRNA in adipocytes of aortic tissue in AS rabbits,reduce blood lipid levels,and help to delay the AS progression.